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| Single-Season Strikeouts per 9IP Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts per 9IP | IP | Year | Career Leaderboard |
| 1. | Steven Williams * | 15.05 | 174.0 | 2004 | |
| 2. | Steven Williams * | 14.12 | 283.7 | 2003 | |
| 3. | Steven Williams * | 13.84 | 278.3 | 2005 | |
| 4. | Arliss Payn | 13.80 | 242.0 | 2005 | |
| 5. | Eric Song | 13.00 | 232.7 | 2003 | |
| 6. | Steven Williams * | 12.90 | 239.3 | 2007 | |
| 7. | Steven Williams * | 12.29 | 256.3 | 2006 | |
| 8. | Steven Williams * | 12.23 | 276.0 | 2008 | |
| 9. | Jose Langlois | 12.22 | 201.0 | 2007 | |
| 10. | James Pineda | 12.12 | 211.7 | 2000 | |
| 11. | Cecil Dowd | 12.09 | 175.7 | 2000 | |
| 12. | Dustin Carrasquillo | 12.02 | 234.3 | 2000 | |
| 13. | Eric Song | 11.93 | 198.3 | 2005 | |
| 14. | Ryan Turner * | 11.89 | 271.7 | 2008 | |
| 15. | Eric Song | 11.85 | 169.3 | 2001 | |
| 16. | Lucas Lara | 11.82 | 262.7 | 2008 | |
| 17. | Eric Song | 11.80 | 241.0 | 2002 | |
| 18. | David Echegaray | 11.78 | 258.3 | 2008 | |
| 19. | Ridge Thompson | 11.63 | 235.3 | 2007 | |
| 20. | Joseph Seybert | 11.59 | 266.3 | 2003 | |
| 21. | Dustin Carrasquillo | 11.56 | 232.0 | 2001 | |
| 22. | Keenan Brochu | 11.35 | 224.3 | 2000 | |
| 23. | Kelly Giuliani | 11.33 | 242.3 | 2002 | |
| 24. | Philip Linton | 11.29 | 228.0 | 2006 | |
| 25. | David Evans | 11.29 | 237.7 | 2001 | |
| 26. | Philip Linton | 11.26 | 203.0 | 2007 | |
| 27. | Richard Eaker | 11.25 | 229.7 | 2000 | |
| 28. | Richard Eaker | 11.19 | 208.3 | 2001 | |
| 29. | Ridge Thompson | 11.12 | 191.0 | 2008 | |
| 30. | James Yim * | 11.10 | 304.0 | 2007 | |
| 31. | Kelly Giuliani | 11.09 | 280.0 | 2003 | |
| 32. | Alfred Raskin | 11.08 | 209.7 | 2001 | |
| 33. | Jose Langlois | 11.05 | 180.0 | 2006 | |
| 34. | Eric Song | 11.05 | 183.3 | 2000 | |
| 35. | Joseph Seybert | 10.99 | 267.0 | 2004 | |
| 36. | Alfred Raskin | 10.96 | 185.7 | 2000 | |
| 37. | Joseph Smartt | 10.94 | 228.7 | 2003 | |
| 38. | Eric Song | 10.94 | 172.0 | 2006 | |
| 39. | George Harmon | 10.93 | 213.3 | 2001 | |
| 40. | Steven Williams * | 10.89 | 257.0 | 2002 | |
| 41. | Paul Wendler | 10.88 | 202.7 | 2003 | |
| 42. | James Yim * | 10.86 | 195.7 | 2006 | |
| 43. | Kelly Giuliani | 10.82 | 236.3 | 2004 | |
| 44. | James Yim * | 10.80 | 291.7 | 2008 | |
| 45. | Keenan Brochu | 10.70 | 180.0 | 2001 | |
| 46. | James Yim * | 10.66 | 236.3 | 2004 | |
| 47. | Jose Langlois | 10.65 | 196.0 | 2016 | |
| 48. | Ramon Quintana | 10.59 | 289.0 | 2004 | |
| 49. | Jose Langlois | 10.55 | 226.0 | 2009 | |
| 50. | Jose Langlois | 10.55 | 230.3 | 2005 | |
| 51. | Alan Yelverton | 10.51 | 210.7 | 2000 | |
| 52. | Dustin Carrasquillo | 10.51 | 179.0 | 2003 | |
| 53. | Stanford Heinz | 10.46 | 213.3 | 2025 | |
| 54. | Jose Valdovinos | 10.46 | 220.3 | 2000 | |
| 55. | Stanford Heinz | 10.42 | 203.0 | 2027 | |
| 56. | James Yim * | 10.42 | 243.7 | 2005 | |
| 57. | Angelo Arroyo | 10.39 | 170.7 | 2001 | |
| 58. | Angelo Arroyo | 10.34 | 225.3 | 2002 | |
| 59. | Jose Langlois | 10.33 | 169.0 | 2017 | |
| 60. | Armando Quinonez * | 10.32 | 253.7 | 2002 | |
| 61. | David Evans | 10.30 | 250.7 | 2002 | |
| 62. | Joseph Seybert | 10.30 | 198.3 | 2001 | |
| 63. | Hugh Pullen | 10.28 | 169.0 | 2003 | |
| 64. | Ramon Quintana | 10.24 | 255.7 | 2003 | |
| 65. | Angelo Arroyo | 10.23 | 219.0 | 2000 | |
| 66. | Steven Williams * | 10.21 | 270.7 | 2009 | |
| 67. | Joe O'Malley | 10.21 | 216.0 | 2004 | |
| 68. | Lucas Lara | 10.20 | 192.3 | 2004 | |
| 69. | Joseph Seybert | 10.19 | 211.0 | 2005 | |
| 70. | Skip Burns | 10.17 | 243.3 | 2005 | |
| 71. | Jose Valdovinos | 10.16 | 218.0 | 2001 | |
| 72. | Jose Langlois | 10.10 | 199.7 | 2015 | |
| 73. | David Echegaray | 10.05 | 246.3 | 2016 | |
| 74. | Lucas Lara | 10.02 | 179.7 | 2005 | |
| 75. | Keenan Brochu | 10.02 | 218.3 | 2002 | |
| 76. | Ryan Turner * | 10.01 | 272.3 | 2003 | |
| 77. | Joseph Smartt | 10.01 | 170.0 | 2004 | |
| 78. | David Echegaray | 10.00 | 253.0 | 2018 | |
| 79. | David Echegaray | 9.96 | 244.0 | 2012 | |
| 80. | David Echegaray | 9.95 | 206.3 | 2019 | |
| 81. | David Echegaray | 9.94 | 256.3 | 2020 | |
| 82. | David Echegaray | 9.94 | 279.0 | 2007 | |
| 83. | Joseph Seybert | 9.94 | 189.3 | 2000 | |
| 84. | David Echegaray | 9.92 | 280.3 | 2013 | |
| 85. | David Echegaray | 9.87 | 259.0 | 2014 | |
| 86. | Jesus Aviles | 9.82 | 238.3 | 2003 | |
| 87. | Dustin Carrasquillo | 9.74 | 248.7 | 2005 | |
| 88. | Alfred Marenco | 9.71 | 268.0 | 2007 | |
| 89. | Lucas Lara | 9.68 | 245.3 | 2006 | |
| 90. | David Evans | 9.68 | 229.7 | 2000 | |
| 91. | David Evans | 9.68 | 217.7 | 2003 | |
| 92. | David Echegaray | 9.67 | 227.0 | 2017 | |
| 93. | Jose Langlois | 9.65 | 225.7 | 2004 | |
| 94. | Skip Burns | 9.65 | 241.7 | 2004 | |
| 95. | Stanford Heinz | 9.64 | 229.7 | 2029 | |
| 96. | Alfred Marenco | 9.64 | 255.0 | 2006 | |
| 97. | Oren Dehart | 9.62 | 243.3 | 2004 | |
| 98. | James Yim * | 9.60 | 219.3 | 2019 | |
| 99. | James Yim * | 9.60 | 259.7 | 2012 | |
| 100. | George Harmon | 9.60 | 235.3 | 2002 |
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