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| Single-Season Saves Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Saves | IP | Year | Career Leaderboard |
| 1. | Allen Sampley | 51 | 86.3 | 2018 | |
| Donald Granger * | 51 | 69.3 | 2003 | ||
| Jewel Brown | 51 | 71.7 | 2002 | ||
| 4. | Carmelo Zarzuela | 50 | 78.7 | 2024 | |
| Tyler Lattimore | 50 | 72.0 | 2023 | ||
| 6. | Wayne Rossignol | 48 | 90.0 | 2027 | |
| Ivan Banabila | 48 | 70.3 | 2017 | ||
| Jewel Brown | 48 | 66.3 | 2005 | ||
| Thomas Shipp | 48 | 75.3 | 2000 | ||
| 10. | Arron Ledford | 47 | 73.0 | 2026 | |
| Amor Aguaijo | 47 | 87.0 | 2023 | ||
| Deangelo Ramos * | 47 | 82.0 | 2014 | ||
| Jewel Brown | 47 | 65.3 | 2007 | ||
| 14. | Paul Rocha | 46 | 78.7 | 2027 | |
| Tyler Lattimore | 46 | 70.0 | 2022 | ||
| Arron Ledford | 46 | 81.3 | 2021 | ||
| Hugo Holt * | 46 | 84.3 | 2010 | ||
| Thomas Mercier | 46 | 79.3 | 2006 | ||
| Milan Pickles | 46 | 71.3 | 2002 | ||
| 20. | Tyler Lattimore | 45 | 89.7 | 2021 | |
| Russell Henikar | 45 | 70.0 | 2021 | ||
| Amor Aguaijo | 45 | 69.3 | 2021 | ||
| Donald Granger * | 45 | 73.0 | 2010 | ||
| Donald Granger * | 45 | 64.3 | 2009 | ||
| Deangelo Ramos * | 45 | 69.7 | 2007 | ||
| Tommy McKinley | 45 | 70.7 | 2004 | ||
| Robert Dolin | 45 | 71.7 | 2003 | ||
| Earnest Hunziker | 45 | 82.3 | 2001 | ||
| 29. | Alan Jacobs | 44 | 71.7 | 2029 | |
| Ken Miguel | 44 | 72.0 | 2027 | ||
| Kelly Crumb | 44 | 70.0 | 2027 | ||
| Arron Ledford | 44 | 76.0 | 2024 | ||
| Jason Leaper | 44 | 68.0 | 2024 | ||
| Brandon Tanner | 44 | 73.3 | 2023 | ||
| Arron Ledford | 44 | 67.0 | 2023 | ||
| Amor Aguaijo | 44 | 76.0 | 2020 | ||
| Billy-Bob Suggs | 44 | 78.7 | 2018 | ||
| Thomas Mercier | 44 | 69.7 | 2012 | ||
| Joaquin Govea | 44 | 82.3 | 2010 | ||
| John Baptista * | 44 | 60.7 | 2008 | ||
| John Baptista * | 44 | 67.7 | 2007 | ||
| Tommy McKinley | 44 | 71.0 | 2005 | ||
| Jewel Brown | 44 | 64.7 | 2003 | ||
| Robert Dolin | 44 | 80.0 | 2000 | ||
| 45. | Tyler Lattimore | 43 | 68.3 | 2026 | |
| Leonard Cadena | 43 | 82.0 | 2024 | ||
| Jason Leaper | 43 | 68.3 | 2023 | ||
| Leonard Cadena | 43 | 59.0 | 2022 | ||
| Jack Teitelbaum | 43 | 71.7 | 2018 | ||
| Joseph Melboure | 43 | 68.0 | 2018 | ||
| Mark Hart | 43 | 73.0 | 2017 | ||
| Lamar Fox | 43 | 67.0 | 2016 | ||
| Eric Duty | 43 | 81.0 | 2012 | ||
| Pierre Puente | 43 | 76.7 | 2012 | ||
| Jeromy Tavares | 43 | 60.7 | 2009 | ||
| Tony Paz | 43 | 59.0 | 2009 | ||
| Donald Granger * | 43 | 62.7 | 2008 | ||
| Donald Granger * | 43 | 62.3 | 2007 | ||
| Diego Castillo * | 43 | 74.3 | 2003 | ||
| Chung Westbrook | 43 | 59.7 | 2002 | ||
| Diego Castillo * | 43 | 74.0 | 2000 | ||
| 62. | Tyler Lattimore | 42 | 68.7 | 2029 | |
| Amor Aguaijo | 42 | 81.0 | 2027 | ||
| Tyler Lattimore | 42 | 66.0 | 2024 | ||
| Art Toczek * | 42 | 87.7 | 2022 | ||
| Henrique Reynoso | 42 | 92.7 | 2019 | ||
| Allen Sampley | 42 | 80.7 | 2019 | ||
| Miguel Cortes Jr | 42 | 82.7 | 2018 | ||
| Miguel Cortes Jr | 42 | 76.7 | 2017 | ||
| Arnie Stier | 42 | 97.0 | 2016 | ||
| Deangelo Ramos * | 42 | 71.0 | 2012 | ||
| Jesus Torres | 42 | 65.0 | 2008 | ||
| Simon Munoz | 42 | 58.0 | 2007 | ||
| Richard McPherson | 42 | 69.3 | 2006 | ||
| Robert Dolin | 42 | 66.3 | 2004 | ||
| Jeremy Wheaton | 42 | 76.3 | 2000 | ||
| 77. | Alan Jacobs | 41 | 70.7 | 2027 | |
| Ken Miguel | 41 | 64.0 | 2026 | ||
| Kelly Crumb | 41 | 92.3 | 2025 | ||
| Henrique Reynoso | 41 | 82.3 | 2020 | ||
| Henrique Reynoso | 41 | 112.0 | 2018 | ||
| Allen Sampley | 41 | 78.3 | 2017 | ||
| Deangelo Ramos * | 41 | 73.0 | 2017 | ||
| Leonard Magnan | 41 | 76.3 | 2015 | ||
| John Hahn | 41 | 81.0 | 2013 | ||
| John Baptista * | 41 | 81.3 | 2011 | ||
| Eric Duty | 41 | 74.3 | 2011 | ||
| Deangelo Ramos * | 41 | 62.7 | 2010 | ||
| Jewel Brown | 41 | 64.0 | 2006 | ||
| Joaquin Govea | 41 | 69.7 | 2004 | ||
| Diego Castillo * | 41 | 68.3 | 2002 | ||
| Michael Odom | 41 | 83.7 | 2001 | ||
| Robert Dolin | 41 | 77.7 | 2001 | ||
| Richard McPherson | 41 | 69.3 | 2001 | ||
| 95. | Ken Miguel | 40 | 64.0 | 2028 | |
| Paul Rocha | 40 | 60.3 | 2026 | ||
| Amor Aguaijo | 40 | 76.7 | 2024 | ||
| Jason Leaper | 40 | 78.3 | 2021 | ||
| Carmelo Zarzuela | 40 | 65.0 | 2021 | ||
| Rafael Souza | 40 | 72.7 | 2020 |
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