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| Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Summer Nelson * | 188 | 718 | 2001 | |
| 2. | Michael Koo Jr * | 181 | 670 | 2001 | |
| 3. | Brian Marshall * | 178 | 762 | 2000 | |
| 4. | Joseph Mentzer | 176 | 697 | 2008 | |
| 5. | Terrance Minor | 173 | 703 | 2001 | |
| 6. | Hugo Grimm | 171 | 706 | 2001 | |
| 7. | Joel Camacho | 170 | 698 | 2001 | |
| 8. | Carlos Salazar | 167 | 532 | 2001 | |
| 9. | Pete Kahle * | 166 | 709 | 2000 | |
| 10. | Oscar Kent | 165 | 689 | 2007 | |
| Numbers Steven | 165 | 651 | 2007 | ||
| Josh Kapaun | 165 | 641 | 2000 | ||
| 13. | Oscar Oakley | 164 | 673 | 2008 | |
| 14. | Christopher Cortese | 163 | 662 | 2006 | |
| 15. | Ralph Montgomery | 162 | 625 | 2007 | |
| Carlos Salazar | 162 | 599 | 2002 | ||
| Josh Kapaun | 162 | 704 | 2001 | ||
| 18. | Jerrold Dukes | 161 | 621 | 2008 | |
| Michael Mooney | 161 | 638 | 2007 | ||
| Joseph Mentzer | 161 | 621 | 2007 | ||
| Juan Castillo | 161 | 628 | 2001 | ||
| Summer Nelson * | 161 | 660 | 2000 | ||
| 23. | Harold Knight | 160 | 646 | 2007 | |
| Brian Marshall * | 160 | 757 | 2001 | ||
| Edwin Coppedge | 160 | 644 | 2000 | ||
| 26. | Juan Castillo | 158 | 654 | 2000 | |
| 27. | Gareth Eisen | 157 | 597 | 2008 | |
| Jason Wallin | 157 | 580 | 2008 | ||
| Hal Rehm | 157 | 613 | 2007 | ||
| 30. | Alex Garza * | 156 | 602 | 2008 | |
| Chet Rinehart | 156 | 578 | 2008 | ||
| 32. | Carl Wesolowski | 155 | 605 | 2005 | |
| Francisco Magana | 155 | 705 | 2000 | ||
| 34. | Delmar Barrie | 154 | 656 | 2008 | |
| Adrian Ahmad | 154 | 625 | 2008 | ||
| Steven Huggan | 154 | 596 | 2007 | ||
| 37. | Jacinto Cepeda | 153 | 498 | 2008 | |
| Andrew Rath | 153 | 635 | 2005 | ||
| 39. | Josh Kapaun | 152 | 600 | 2007 | |
| Carl Wesolowski | 152 | 670 | 2006 | ||
| Joseph Sharkey | 152 | 697 | 2001 | ||
| 42. | Carl Wesolowski | 151 | 615 | 2008 | |
| Joseph Mentzer | 151 | 639 | 2006 | ||
| 44. | Steven Huggan | 150 | 639 | 2015 | |
| Roy Lininger | 150 | 656 | 2007 | ||
| Sully Sullivan * | 150 | 565 | 2007 | ||
| Johnny Carmona | 150 | 579 | 2006 | ||
| 48. | Armando Mesa | 149 | 613 | 2007 | |
| Barney King | 149 | 565 | 2007 | ||
| Chris Lott | 149 | 612 | 2005 | ||
| Nobukazu Takemura | 149 | 695 | 2004 | ||
| Josh Kapaun | 149 | 607 | 2003 | ||
| 53. | Christopher Stormes * | 148 | 627 | 2008 | |
| Oscar Fetters | 148 | 603 | 2008 | ||
| Ludwig Claus | 148 | 565 | 2007 | ||
| Tony Ocejo * | 148 | 579 | 2005 | ||
| Bill Long | 148 | 710 | 2001 | ||
| Tyler Utah | 148 | 672 | 2000 | ||
| 59. | Chet Rinehart | 147 | 597 | 2007 | |
| Josh Kapaun | 147 | 597 | 2004 | ||
| 61. | Howard Luther | 146 | 585 | 2007 | |
| Bill Long | 146 | 674 | 2005 | ||
| Tony Batiste | 146 | 590 | 2003 | ||
| Terrance Minor | 146 | 633 | 2002 | ||
| Bill Long | 146 | 713 | 2000 | ||
| 66. | Dennis Thiele | 145 | 605 | 2005 | |
| Carol Hoover | 145 | 665 | 2004 | ||
| Robert Smith | 145 | 643 | 2003 | ||
| Kelvin Varga | 145 | 664 | 2000 | ||
| 70. | Juan Castillo | 144 | 612 | 2004 | |
| Joseph Mentzer | 144 | 575 | 2004 | ||
| Francisco Magana | 144 | 647 | 2002 | ||
| Tyler Utah | 144 | 709 | 2001 | ||
| Francisco Magana | 144 | 698 | 2001 | ||
| William Maxon | 144 | 702 | 2000 | ||
| 76. | Roy Lininger | 143 | 629 | 2008 | |
| Ludwig Claus | 143 | 595 | 2008 | ||
| Sully Sullivan * | 143 | 567 | 2006 | ||
| Chet Rinehart | 143 | 583 | 2005 | ||
| Thomas Holtzclaw | 143 | 687 | 2000 | ||
| Renaldo Loera | 143 | 685 | 2000 | ||
| 82. | Alfred Cazares | 142 | 569 | 2008 | |
| Alton Torres | 142 | 537 | 2007 | ||
| Michael Mooney | 142 | 646 | 2006 | ||
| Numbers Steven | 142 | 629 | 2006 | ||
| Tony Lack | 142 | 557 | 2005 | ||
| Dennis Thiele | 142 | 593 | 2004 | ||
| Joseph Mentzer | 142 | 601 | 2003 | ||
| John Ross | 142 | 590 | 2003 | ||
| Pete Kahle * | 142 | 702 | 2001 | ||
| Edwin Coppedge | 142 | 641 | 2001 | ||
| 92. | Carlos Pena | 141 | 643 | 2015 | |
| Bill Long | 141 | 633 | 2006 | ||
| Joseph Sharkey | 141 | 653 | 2002 | ||
| James Roselli | 141 | 682 | 2001 | ||
| Kenny Jay | 141 | 603 | 2000 | ||
| 97. | Danny Rayborn | 140 | 597 | 2007 | |
| Grady McDonaghey * | 140 | 613 | 2006 | ||
| Alesso Rusticucci | 140 | 650 | 2005 | ||
| Christopher Cortese | 140 | 623 | 2005 |
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